For an oocyte to become ready for fertilization and growth into an embryo, the right list of genes ought to be turned on. Namekawa suspected this pre-programming from the oocyte genome happens in numerous phases — the 1st 1 starting within the time a feminine is born. He thought that chromatin remodeling proteins did Substantially of the function, by shifting spools all over.
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By the time a human female is born, her developing ovaries by now have each of the egg cells, or “oocytes,” that she will ovulate about the program of her reproductive existence.
Every one consists of a mass of thread-like DNA — akin to 400 miles of yarn. To keep it from devolving right into a tangle, the DNA is wrapped all-around a series of protein spools, called nucleosomes.
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